Wellcome Trust Centre For Mitochondrial Research

Charlotte Warren


I have completed all my studies here at Newcastle University, graduating with a BSc undergraduate degree in Physiological Sciences and a Masters of Research in Neuroscience. It was during my masters’ project that I was first introduced to the Mitochondrial Research Group and became interested in the field, in particular, its links to exercise and ageing. I am now completing my PhD within the group.

Research Project: Mitochondrial abnormalities in sarcopenia

Principal Investigators: Prof Sir Doug Turnbull

Project Details: 

My project will aim to investigate the role of mitochondria in the development of sarcopenia. Over the 3 years I will look to address a number of key questions:

  • The phenomenology behind sarcopenia and muscle ageing- To understand how mitochondrial DNA mutations clonally expand as we age.
  • To understand the consequences of mitochondrial respiratory chain deficiencies at the cellular level and whether this changes with age
  • To explore the use of exercise as a potential intervention for sarcopenia and respiratory chain deficiencies