Mitochondrial diseases are an important group of inherited disorders that result in a defective mitochondrial respiratory chain. Despite this, the management of these conditions remains a poorly researched area and there is little expert advice available for the treatment of specific aspects of mitochondrial disease. Multi system involvement is also common and this can pose additional management dilemmas for doctors. The Newcastle Mitochondrial Disease Clinical Guidelines aim to provide expert guidance to health professionals in the management of mitochondrial disease.

Within these pages we aim to offer guidance on specific aspects of mitochondrial disease. We have started by publishing the ‘Cardiac Guidelines in Adult Mitochondrial Disease’, but will add additional guidelines as soon as they are available. Until then, guidance can be accessed from the Newcastle Mitochondrial Team as it has been in the past, either in The Mitochondrial Clinic or by contacting one of the mitochondrial team directly.

The guidelines have been developed using consensus expert opinion sourced from the National Commissioning Group Service for Rare Mitochondrial Diseases for Adults and Children in Newcastle with associated experts from other hospitals.

Mitochondrial Consensus Guidelines

• Consensus based statements for the management of stroke-like episodes
• Safety of drug use in patients with mitochondrial disease

Mitochondrial Clinical Guidelines

• Anaesthesia Peri-Operative Care Guidelines
• Updated Cardiology Guidelines
• Updated Diabetes Guidelines
• Epilepsy Guidelines
• Gastrointestinal Guidelines
• Neuropathy Guidelines
• Ophthalmology Guidelines
• Pregnancy Guidelines
• Respiratory Guidelines
• Paediatric constipation guidelines
• Physiotherapy Guidelines

At A Glance Clinical Guidelines

• At a Glance Anaesthesia and Peri-Operative Guidelines
• At a Glance Cardiology Guidelines
• At a Glance Epilepsy Guidelines
• At a Glance Gastrointestinal Guidelines
  
• At a Glance Neuropathy Guidelines
  
• At a Glance Ophthalmology Guidelines
• At a Glance Pregnancy Guidelines
• At a Glance Respiratory Guidelines
• At a Glance Paediatric Screening and Surveillance Guidelines
• At a Glance Paediatric Varicella Vaccine Guidelines
• At a Glance Paediatric Constipation Guidelines
• At a Glance Paediatric Perioperative Guidelines
• At a Glance Physiotherapy Guidelines
• At a Glance Adult Lower Urinary Tract Dysfunction Guidelines