Wellcome Trust Centre For Mitochondrial Research

Amy Vincent

Biography

I completed my undergraduate study at The University of Nottingham, graduating with an upper second class MSci degree in Biochemistry and Genetics. I have now been at the Wellcome Trust Centre for Mitochondrial Research for 3 years and am soon to complete my PhD.

Research Project

Investigating mitochondrial dysfunction in mitochondrial myopathies and other myopathies.

Principal Investigators: Professor Robert Taylor, and Professor Doug Turnbull

Project Details

My PhD, has spanned a number of projects with the aim to investigate mitochondrial dysfunction in both mitochondrial myopathy and other neuromuscular diseases. My current work focuses on:  i) understanding the mechanism by which mitochondrial DNA mutations accumulate in age and disease, ii) three-dimensional quantification of the morphology of mitochondria in human skeletal muscle and iii) looking to understand the links between mitochondrial ultrastructure and function

Contact: a.vincent2@newcastle.ac.uk
Sponsor/funder: MRC
Collaborators: Asst. Prof. Martin Picard (Columbia University) and Dr Matt Hall (UCL)
External links:

ResearchGate

LinkedIn

Publications:

Amy E. Vincent, John P. Grady, Mariana C. Rocha, Charlotte L. Alston, Karolina A. Rygiel, Rita Barresi, Robert W. Taylor, Doug M. Turnbull: Mitochondrial dysfunction in myofibrillar myopathy. Neuromuscular Disorders 08/2016;  DOI:10.1016/j.nmd.2016.08.004

Amy E. Vincent, Hannah S. Rosa, Charlotte L. Alston, John P. Grady, Karolina A. Rygiel, Mariana C. Rocha Rita Barresi, Robert W. Taylor, Doug M. Turnbull: Dysferlin mutations and mitochondrial dysfunction. Neuromuscular Disorders 08/2016;  10.1016/j.nmd.2016.08.008

Amy E Vincent, Yi Shiau Ng, Kathryn White, Tracey Davey, Carmen Mannella, Gavin Falkous, Catherine Feeney, Andrew M Schaefer, Robert Mcfarland, Grainne S Gorman, Robert W Taylor, Doug M Turnbull, Martin Picard: The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy. Scientific Reports 09/2016; 6. DOI:10.1038/srep30610

Martin Picard, Amy E Vincent, Doug M. Turnbull: Expanding Our Understanding of mtDNA Deletions. Cell Metabolism 07/2016; 24(1). DOI:10.1016/j.cmet.2016.06.024

Virgilio J. J. Cadete, Sonia Deschênes, Alexanne Cuillerier, François Brisebois, Ayumu Sugiura, Amy Vincent, Doug Turnbull, Martin Picard, Heidi M. McBride, Yan Burelle: Formation of Mitchondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system. The Journal of Physiology 06/2016;  DOI:10.1113/JP272703

Karolina A. Rygiel, Helen A. Tuppen, John P. Grady, Amy Vincent, Emma L. Blakely, Amy K. Reeve, Robert W. Taylor, Martin Picard, James Miller, Doug M. Turnbull: Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis. Nucleic Acids Research 04/2016; 44(11). DOI:10.1093/nar/gkw382

Mariana C Rocha, John P Grady, Anne Grünewald, Amy Vincent, Philip F Dobson, Robert W Taylor, Doug M Turnbull, Karolina A Rygiel: A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: Understanding mechanisms and improving diagnosis. Scientific Reports 10/2015; 5. DOI:10.1038/srep15037