I completed my undergraduate study at The University of Nottingham, graduating with an upper second class MSci degree in Biochemistry and Genetics. I have now been at the Wellcome Trust Centre for Mitochondrial Research for 3 years and am soon to complete my PhD.
Investigating mitochondrial dysfunction in mitochondrial myopathies and other myopathies.
My PhD, has spanned a number of projects with the aim to investigate mitochondrial dysfunction in both mitochondrial myopathy and other neuromuscular diseases. My current work focuses on: i) understanding the mechanism by which mitochondrial DNA mutations accumulate in age and disease, ii) three-dimensional quantification of the morphology of mitochondria in human skeletal muscle and iii) looking to understand the links between mitochondrial ultrastructure and function
Collaborators: Asst. Prof. Martin Picard (Columbia University) and Dr Matt Hall (UCL)
Amy E. Vincent, John P. Grady, Mariana C. Rocha, Charlotte L. Alston, Karolina A. Rygiel, Rita Barresi, Robert W. Taylor, Doug M. Turnbull: Mitochondrial dysfunction in myofibrillar myopathy. Neuromuscular Disorders 08/2016; DOI:10.1016/j.nmd.2016.08.004
Amy E. Vincent, Hannah S. Rosa, Charlotte L. Alston, John P. Grady, Karolina A. Rygiel, Mariana C. Rocha Rita Barresi, Robert W. Taylor, Doug M. Turnbull: Dysferlin mutations and mitochondrial dysfunction. Neuromuscular Disorders 08/2016; 10.1016/j.nmd.2016.08.008
Amy E Vincent, Yi Shiau Ng, Kathryn White, Tracey Davey, Carmen Mannella, Gavin Falkous, Catherine Feeney, Andrew M Schaefer, Robert Mcfarland, Grainne S Gorman, Robert W Taylor, Doug M Turnbull, Martin Picard: The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy. Scientific Reports 09/2016; 6. DOI:10.1038/srep30610
Martin Picard, Amy E Vincent, Doug M. Turnbull: Expanding Our Understanding of mtDNA Deletions. Cell Metabolism 07/2016; 24(1). DOI:10.1016/j.cmet.2016.06.024
Virgilio J. J. Cadete, Sonia Deschênes, Alexanne Cuillerier, François Brisebois, Ayumu Sugiura, Amy Vincent, Doug Turnbull, Martin Picard, Heidi M. McBride, Yan Burelle: Formation of Mitchondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system. The Journal of Physiology 06/2016; DOI:10.1113/JP272703
Karolina A. Rygiel, Helen A. Tuppen, John P. Grady, Amy Vincent, Emma L. Blakely, Amy K. Reeve, Robert W. Taylor, Martin Picard, James Miller, Doug M. Turnbull: Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis. Nucleic Acids Research 04/2016; 44(11). DOI:10.1093/nar/gkw382
Mariana C Rocha, John P Grady, Anne Grünewald, Amy Vincent, Philip F Dobson, Robert W Taylor, Doug M Turnbull, Karolina A Rygiel: A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: Understanding mechanisms and improving diagnosis. Scientific Reports 10/2015; 5. DOI:10.1038/srep15037