Wellcome Trust Centre For Mitochondrial Research

Dr John Grady


grady scaleI am a post-doctoral researcher in the Mitochondrial Research group, having completed my PhD here at the end of 2013. My background is in statistics and computing; prior to beginning my PhD I worked for ten years as an IT systems developer and database designer, working in the financial sector and international development. As well as my research into clinical disease progression, I am responsible for development and maintenance of the database for the MRC Mitochondrial Disease cohort http://mitochondrialdisease.nhs.uk/research/events/

I work under the supervision of Prof Doug Turnbull. I also collaborate regularly with many other researchers in the group in a more general role of data and statistical support.

Research Project

Statistical Modelling of Mitochondrial Disease Progression

Principal Investigators: Professor Doug Turnbull, Dr Robert McFarland and Professor Rob Taylor

Other staff members involved: Dr Richard McNally (HIS)

Project Details

Over the last couple of decades there have been remarkable advances in the diagnosis of mitochondrial DNA disease and understanding of the prevalence of these diseases in society. What has been lacking has been real progress in our understanding of the clinical features and management of these patients, and an understanding of expected disease progression in individual patients.

I am using statistical modelling techniques and data collected from patients using the NMDAS (Newcastle Mitochondrial Disease Adult Scale) assessment to better understand how patients progress over time, both as a group and as individuals. We aim to use these techniques to investigate which factors (genetic or otherwise) have significant impact on disease severity and progression. Ultimately, we aim to use the outputs of these statistical models to provide support to clinicians in their care of patients, and help patients in their understanding of how their disease will impact on their lives.

Sponsor/Funder: Wellcome Trust