I have completed all my studies in UQAM University, Montréal, CANADA. My undergraduate study was in Biology with specialization in Toxicology. Following that, I undertook a Master’s degree in Biology in the laboratory of Dr Gilles Gouspillou, in muscular and mitochondrial physiology. Trying to understand the effects of aging and caloric restriction on mitochondrial morphology and dynamics in rat oxidative and glycolytic muscles. During this time, I developed an interest in mitochondrial morphology and dysfunction.
Following this, I am now pursuing a PhD, which involves investigating mitochondrial morphology in skeletal muscle using electron microscopy.
Characterisation mitochondrial morphology in skeletal muscle using electron microscopy.
This study aims to systematically assess mitochondrial morphology in skeletal muscle using electron microscopy. Trying to correlate some of the recent findings in mitochondrial morphology using 3D electron microscopy techniques with biochemical dysfunction of mitochondria, with a focus on a current drug trial.
The project will have two mains parts:
- To optimise methods for detecting respiratory chain deficiency in association with EM in mouse and human skeletal muscle
- To use the above technique to analyse morphology in skeletal muscle samples from patients with m.3243.A>G and single, large-scale mtDNA deletions pre and post treatments with Acipimox or placebo control.
Sponsor/funder: Wellcome Trust/MDC