I qualified from the Royal College of Surgeons in Ireland (RCSI), in 1997 and completed three years of general medical training in Dublin, Ireland. I became medical tutor for third and final medical year students at RCSI, for one year, prior to commencing my clinical training in neurology. After completion of my specialist training, I moved to Newcastle to further my interest in neuromuscular diseases. I am now a Consultant Neurologist and with my colleagues have established the Wellcome Centre for Mitochondrial Research at Newcastle University as an internationally renowned centre of excellence in mitochondrial disease.
I established and now lead the Newcastle Mito Hub – a research group designed to build on the world-class medical science at Newcastle University. I have led the development of clinical operating procedures for this group and hold overall responsibility for its use and governance. The Newcastle Mito Hub is growing to become the clinical platform for therapeutic interventions in mitochondrial medicine research in collaboration between the Wellcome Centre for Mitochondrial Research at Newcastle University and the Newcastle Hospitals Trust.
I have developed research programs on two levels; 1) investigating genotype-phenotype correlations of primary mitochondrial disorders to better understand the basic pathophysiology and improve diagnostic yield (the first translational gap), and 2) Identifying strategic patient-centred research themes and validated outcomes (the second translational gap). I have established clinical trials in mitochondrial disease where there was previously little or no clinical trial research activity in the UK.