Wellcome Trust Centre For Mitochondrial Research

David Houghton

Research Project: Mitochondria – Microbiome Cross Talk in Mitochondrial Disease

Principal Investigators: Professor Doug Turnbull, Dr Laura Greaves, and Dr Grainne Gorman

Project Details:
Gut symptoms are frequent and often debilitating in children and adults with mitochondrial disease. Bacteria within the digestive system, termed ‘gut microbime’ has been linked with excess gas production, malabsorption, abdominal pain, bloating and constipation; non-specific symptoms widely reported in mitochondrial disease. I aim to investigate the complexity and workings of the gut microbiome in mitochondrial disease, providing a unique approach and deeper understanding of the complex microbe:microbe and microbiota–host interactions. The new insights generated here will provide the foundation for interventional studies aimed at manipulating the gut microbiome and relieving disease burden in patients with mitochondrial disease and potentially ageing and diseases associated with mitochondrial dysfunction, such as obesity, diabetes and neuro-degenerative disorders such as dementia and Parkinson’s disease.