During my PhD at Nottingham Trent University, I studied the effects of mitochondrial dysfunction on the organelle’s proteome. I have a particular interest in the interactions between mitochondria and the rest of the cell and how mitochondrial dysfunction leads to cellular deleterious consequences. I also have expertise in biomarker discovery in various diseases.
I am currently working as a research associate on a project led by Dr Patrick Yu-Wai-Man at the Wellcome Trust Centre for Mitochondrial Research. My main focus here is to investigate the mechanisms of retinal ganglion cell loss in patients with mitochondrial optic neuropathies.
Mechanisms of retinal ganglion cell loss in patients with mitochondrial optic neuropathies
Principal Investigators: Dr Patrick Yu-Wai-Man
Mitochondrial optic neuropathies affect at least 1 in 10,000 individuals. It is characterised by chronic visual impairment mainly caused by degeneration of ganglion retinal cells. Some patients will only develop eye problems, whilst others, sometimes in the same family, will develop extraocular symptoms also affecting the brain, skeletal muscle and peripheral nerves.
The aim of my project is to establish models of optic nerve degeneration in these groups of mitochondrial disorders. These models will allow me to investigate the selective susceptibility of the retinal ganglion cells to mitochondrial disease and to understand why some patients develop extraocular symptoms, whilst others do not.