Wellcome Trust Centre For Mitochondrial Research

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Dr Helene Plun-Favreau from UCL Queen’s Square Institute of Neurology will be speaking as part of the WCMR seminar series on the 3rd October 2019 from 1-2pm in the CISR.

The ultimate goal of Dr Plun-Favreau’s research is to identify compounds that are able to modulate mitophagy and rescue mitochondrial pathophysiology and neuronal death. Her lab focuses on the following themes:

– Understanding further the mitophagy process

– Identifying the major molecular players in PINK1-induced mitophagy.

– Unravelling the upstream pathways that regulate the mitophagy process.

– Assessing mitophagy and other mitochondrial dysfunctions in iPSC-derived neurons from patients with Parkinson’s disease, and with other neurodegenerative diseases (E.g Alzheimer’s disease, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, mitochondrial DNA disease etc).